Spatial and cellular composition of lung fibrosis induced by multi-walled carbon nanotubes - PubMed
3 days ago
- #lung fibrosis
- #MWCNTs
- #lung-gut axis
- Study investigates lung fibrosis induced by multi-walled carbon nanotubes (MWCNTs) and its effects on gut homeostasis.
- MWCNTs exposure leads to spatial reorganization of pulmonary cellular architecture, with macrophage- and fibroblast-enriched clusters.
- Slamf7-Slamf7 interactions identified as key drivers of macrophage superactivation, leading to excessive pro-inflammatory cytokine release.
- Knockdown of Slamf7 in alveolar macrophages attenuates superactivation.
- Macrophage superactivation alters serum metabolic profiles, affecting energy metabolism and inflammation pathways.
- Lung injury extends to the distal intestine, compromising rectal epithelial barrier integrity and causing microbial and metabolic imbalance.
- Findings provide mechanistic evidence for the lung-gut link described in traditional Chinese medicine.
- Study highlights potential hazards of inhaled MWCNTs and identifies molecular targets to mitigate nanomaterial immunotoxicity.