Exosomes as Cellular Communicators and Therapeutic Agents in Orthopedic Diseases: From Mechanisms to Intervention - PubMed
7 hours ago
- #exosomes
- #therapeutic agents
- #orthopedic diseases
- Exosomes play a critical role in intercellular communication in orthopedic diseases.
- They regulate bone remodeling, cartilage homeostasis, and inflammatory responses.
- Current therapies often fail to achieve complete tissue repair in orthopedics.
- Exosome secretion and cargo loading are influenced by physical, chemical, biological, and pharmacological factors.
- Engineered exosomes show potential as targeted therapeutic strategies.
- Challenges include standardization of isolation, drug-loading efficiency, and large-scale production.
- Clinical application is limited by unclear in vivo metabolic mechanisms and lack of efficacy evaluation systems.