The C-reactive Protein-Triglyceride-Glucose Index in Relation to Liver Disease - PubMed
5 hours ago
- #risk-prediction
- #metabo-inflammatory-marker
- #liver-disease
- The study investigates the predictive value of the C-reactive protein-triglyceride-glucose index (CTI) for liver disease events in middle-aged and older populations.
- Data from the China Health and Retirement Longitudinal Study (CHARLS) was used, specifically from the 2011 and 2015 waves that included blood samples.
- A time-dependent Cox regression model showed that each 1-unit increase in CTI was associated with a 21.0% higher risk of liver disease.
- Each quartile increase in baseline CTI was linked to a 12.2% elevated risk of liver disease, with results remaining robust in sensitivity analyses.
- The CTI model demonstrated better fit and slightly higher discriminatory ability compared to single-marker models (TyG index and CRP alone).
- This is the first study to show CTI as an independent and robust predictor of liver disease in a nationally representative cohort.
- The CTI can be used to identify high-risk individuals, offering a novel tool for early warning of liver disease.