Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex - PubMed
6 hours ago
- #heme transport
- #T. spiralis
- #Bafilomycin A1
- Bafilomycin A1 shows promise as a therapeutic agent against T. spiralis infection.
- T. spiralis lacks autonomous heme synthesis and scavenges heme from the host using an aspartic protease.
- Ts-HRG-1 and Ts-ATP6V0C form a functional complex crucial for heme transport in T. spiralis.
- Inhibition of Ts-ATP6V0C with Bafilomycin A1 impairs heme uptake, causing developmental arrest and reduced larval burden.
- Targeting HRG-1-interacting proteins presents a new direction for anthelminthic drug research.