Myocardial fibrosis and glycolysis: a bibliometric study and visualization analysis (2000-2024) - PubMed

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Myocardial fibrosis is linked to glycolytic dysregulation in cardiovascular diseases.
A bibliometric study analyzed 408 articles from 2000-2024 using CiteSpace and VOSviewer.
Research output increased from 1 article in 2000 to 51 in 2024, with three phases: Initial Exploration, Slow Fluctuation, and Rapid Development.
The U.S. (32%) and China (20%) were the leading contributors to research on myocardial fibrosis and glycolysis.
Top institutions included Univ. of Alberta (15 studies) and Univ. of Utah (14 studies).
Core authors were Archer, S.L. (10 studies) and Chen, J.-X. (8 studies), with Lopaschuk, G.D. being the most co-cited (117 times).
High-frequency keywords included 'heart failure', 'expression', 'metabolism', and 'glycolysis'.
Emerging research frontiers are 'extracellular matrix' and 'pulmonary hypertension'.
Clustering analysis identified 10 clusters, including pulmonary arterial hypertension and mitochondrial dysfunction.
Key trends include U.S. and China leading collaborative networks, glycolytic reprogramming as a focus, and mitochondrial dysfunction as an emerging frontier.

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