Fibroblast-derived BMP5 promotes tendon adhesion by inducing bone marrow mesenchymal stromal cells to differentiate into myofibroblasts - PubMed
4 days ago
- #Paclitaxel
- #BMP5
- #Tendon Adhesion
- Fibroblast-derived BMP5 promotes tendon adhesion by inducing bone marrow mesenchymal stromal cells (MSCs) to differentiate into myofibroblasts.
- Paclitaxel (PTX) suppresses BMP5 expression in fibroblasts by inhibiting the HIF-1α pathway, blocking MSC-to-myofibroblast transition.
- Polylactic acid (PLA) membranes with PTX (PLB and PLC forms) were developed for sustained local delivery, with PLC showing controlled release, reduced cytotoxicity, and superior anti-adhesion efficacy.
- The study identifies BMP5 as a key driver of tendon adhesion and proposes PTX-loaded PLC membranes as a therapeutic strategy.