The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation - PubM
4 hours ago
- #microbiome
- #diabetes
- #metabolism
- Indole, a microbial tryptophan metabolite, enhances GLP-1 secretion and improves glucose homeostasis in diabetic mice.
- Indole stimulates GLP-1 secretion in a concentration-dependent manner in vitro and improves acute glucose management in vivo.
- Indole promotes enteroendocrine L cell differentiation in murine ileal organoids, increasing L cell density and long-term glucoregulatory benefits.
- Sub-chronic indole administration improves glucose tolerance and insulin sensitivity in a type 2 diabetes mouse model.
- The study suggests potential for indole as a nutraceutical supplement for diabetes treatment or prevention.
- Highlights the role of gut microbiota-derived metabolites in metabolic health and diabetes management.