Diacerein for Knee Osteoarthritis: A Randomized Clinical Trial - PubMed
5 hours ago
- #diacerein
- #clinical trial
- #osteoarthritis
- Diacerein was tested for knee osteoarthritis (OA) in a randomized clinical trial.
- The study included 262 participants with knee OA, pain, and inflammation (effusion-synovitis).
- Participants received either diacerein (50 mg, increasing to twice daily) or placebo for 24 weeks.
- No significant difference in knee pain improvement was found between diacerein and placebo groups.
- Common adverse effects included gastrointestinal symptoms, especially diarrhea, more frequent in the diacerein group.
- The study concluded that diacerein is not effective for knee pain in OA patients with inflammation.