Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications for Human Aging and Longevity - PubMed
5 hours ago
- #aging
- #natural-products
- #autophagy
- Autophagy is a crucial intracellular process for maintaining cellular homeostasis, which becomes dysregulated with aging.
- Bioactive natural products from plants, foods, and marine organisms can modulate autophagy, offering potential anti-aging benefits.
- These compounds regulate autophagy via key pathways like AMPK, PI3K/AKT/mTOR, SIRT1, and FOXO, and mitigate oxidative stress and inflammation.
- Natural compounds such as polyphenols, flavonoids, alkaloids, terpenoids, and carotenoids can restore autophagic flux and prevent excessive autophagy-induced cell death.
- The review discusses both experimental and clinical evidence supporting the geroprotective effects of autophagy-modulating natural products.
- Challenges include bioavailability and dose-dependent effects, but these compounds hold promise for aging intervention strategies.