4-Hydroxyphenanthrene exacerbates obesity by altering gut microbiota and bile acid metabolism - PubMed
5 hours ago
- #bile acid metabolism
- #obesity
- #gut microbiota
- 4-Hydroxyphenanthrene (4-OHPhe) exposure is linked to increased obesity risk.
- 4-OHPhe downregulates hydroxylamine reductase (hcp) genes in Bacteroides uniformis, reducing its abundance.
- Decline in B. uniformis lowers hyodeoxycholic acid (HDCA) production, affecting the FXR-ceramide pathway.
- This pathway downregulates white adipose tissue (WAT) thermogenic genes, leading to obesity in male mice.
- B. uniformis administration and HDCA treatment can counteract the obesity-promoting effects of 4-OHPhe.