NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors - PubMed
5 hours ago
- #immune memory
- #CAR-T therapy
- #solid tumors
- NR2F6 deletion enhances CAR-T cell function in solid tumors by maintaining a TCF1+ progenitor-exhausted phenotype.
- Improved metabolic fitness and cytotoxic potency of CAR-T cells under chronic antigen exposure.
- Nr2f6-deficient CAR-T cells induce robust host antitumor responses, including protection against antigen-negative tumors.
- Durable tumor control involves epitope spreading and secondary immune responses, likely via dendritic cell reactivation.
- NR2F6 inhibition presents a promising strategy for durable, antigen-agnostic immunotherapy in solid tumors.