"Risk Factors for Secondary Immunodeficiency in the Aged" - PubMed
3 hours ago
- #secondary immunodeficiency
- #vaccination
- #immunosenescence
- Secondary immunodeficiency in the aged is influenced by immunosenescence, which includes inflammaging, reduced immune cell output, and impaired innate function.
- Malnutrition exacerbates immune dysfunction through impaired cell-mediated immunity and micronutrient deficiencies.
- Immunosuppressive therapies, such as corticosteroids and biologics, further weaken the immune system in older adults.
- Comorbidities like chronic kidney/liver disease, diabetes, and persistent viral infections contribute to immune dysregulation.
- Vaccination is a key prevention strategy, with updated immunization against COVID-19, influenza, RSV, herpes zoster, and pneumococcal disease being critical.