Mitochondria acidify lysosomes through membrane contacts - PubMed
5 hours ago
- #lysosome acidification
- #proton flux
- #mitochondria-lysosome contact
- Mitochondria acidify lysosomes through membrane contacts (MLCs).
- Enhanced lysosome content degradation occurs at MLC sites due to acidification.
- A proton flux from mitochondria to lysosomes is observed at MLC sites.
- Close proximity between mitochondria and lysosomes increases lysosome acidification, enhancing digestion.
- This mechanism plays a crucial role in cellular functions and may be relevant under disease conditions.