Unveiling Endotypes in Systemic Lupus Erythematosus Through Multi-Omic Analysis: Insights into Cardiovascular and Renal Complications - PubMed
2 days ago
- #Systemic Lupus Erythematosus
- #Multi-Omic Analysis
- #Cardiovascular Risk
- Study investigates molecular endotypes in Systemic Lupus Erythematosus (SLE) linked to cardiovascular (CV) complications and lupus nephritis (LN).
- Proteomic and metabolomic analysis of 199 SLE patients identified two molecular subgroups (Cluster 1 and Cluster 2).
- Cluster 1 showed higher damage burden, increased lupus nephritis, hypertension, dyslipidemia, obesity, and abnormal CRP/ESR levels.
- 47 inflammatory and organ damage proteins and multiple metabolites were elevated in Cluster 1.
- Neural network models highlighted citrate and lipoproteins as key discriminators between clusters (AUC=0.77).
- Multi-omics analyses confirmed enrichment in pathways related to leukocyte trafficking, endothelial stress, and nephritis.
- In vitro studies showed SLE patient serum induced NF-κB activation in rat kidneys, indicating a pro-inflammatory effect.
- Findings support the potential of multi-omic profiling for precision risk stratification in SLE.