The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion - PubMed
3 days ago
- #immune evasion
- #MARCHF8
- #HPV-positive head and neck cancer
- MARCHF8, a membrane-associated ubiquitin ligase, degrades MHC-I in HPV-positive head and neck cancer (HPV+ HNC) to facilitate immune evasion.
- Inhibition of MARCHF8 restores MHC-I levels, suppresses tumor growth, and increases infiltration of NK and T cells in the tumor microenvironment.
- Marchf8 knockout enhances cross-talk between cytotoxic NK cells, CD8+ T cells, and macrophages, boosting tumor-killing activity.
- Combining Marchf8 knockout with anti-PD-1 treatment improves tumor suppression and immune cell infiltration in immune checkpoint inhibitor-refractory tumors.
- MARCHF8 is identified as a potential immunotherapy target for HPV+ HNC patients.