VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis - PubMed
5 hours ago
- #colitis
- #intestinal stem cells
- #VIPR1
- VIPR1 acts as a neural checkpoint suppressing intestinal stem cell (ISC) regeneration.
- VIP-producing neurons signal to ISCs via VIPR1, restraining hyperproliferation through an ERK-Notum-Wnt/β-catenin axis.
- During colitis, VIPergic neurons expand, worsening epithelial injury by suppressing ISC-driven regeneration.
- Deleting Vipr1 in ISCs or epithelium restores regeneration and alleviates colitis.
- VIPR1's suppressive role is conserved in human intestinal models, suggesting therapeutic potential.