CYP2D6-Guided Opioid Management and Postoperative Pain Control: A Randomized Clinical Trial - PubMed
10 hours ago
- #postoperative pain
- #CYP2D6
- #opioid management
- CYP2D6-guided opioid prescribing was tested in a randomized clinical trial for postoperative pain management.
- Individuals with poor or intermediate CYP2D6 metabolizer phenotypes have lower active metabolite concentrations of certain opioids, increasing the risk of inadequate pain control.
- The trial involved 1602 participants, with 351 having actionable CYP2D6 phenotypes and undergoing surgery.
- Participants in the CYP2D6-guided arm received genotype-based recommendations to avoid tramadol, hydrocodone, and codeine if they were poor or intermediate metabolizers.
- Concordance between opioid treatment and CYP2D6 phenotype was higher in the CYP2D6-guided arm (64%) compared to the control arm (27%).
- No significant differences were found in pain control or opioid use between the CYP2D6-guided and control arms.
- The study concluded that CYP2D6-guided opioid therapy did not improve pain control in the context of multimodal postoperative pain management.