Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model - PubMed
4 hours ago
- #Dopamine Signaling
- #Retinopathy of Prematurity
- #Pathological Neovascularization
- Dopamine (DA) inhibits pathological neovascularization in the oxygen-induced retinopathy (OIR) mouse model, a model for retinopathy of prematurity (ROP).
- Impaired dopamine signaling and D2 receptor (Drd2) activity in Müller cells exacerbate pathological angiogenesis during hypoxia.
- Drd2-mediated signaling in Müller cells regulates hypoxia-inducible factor alpha and vascular endothelial growth factor A biosynthesis in OIR.
- The study suggests targeting dopamine pathways as an alternative strategy to anti-VEGF treatments for ROP.