Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration - PubMed
4 hours ago
- #bone marrow niche
- #YAP/TAZ signaling
- #hematopoietic regeneration
- The bone marrow niche is crucial for hematopoietic stem cell support and regeneration.
- Myeloablative stress damages both hematopoietic stem/progenitor cells and niche cells like endothelial cells and mesenchymal stromal cells.
- YAP/TAZ activation in MSCs and ECs responds to bone marrow injury, aiding niche recovery.
- YAP/TAZ maintain MSC multipotency, regulate transcription factors (Ebf1/Ebf3), and promote hematopoietic/angiogenic factors.
- YAP/TAZ signaling coordinates vascular remodeling and HSC retention post-injury.
- Pharmacological YAP/TAZ activation enhances niche reorganization and hematopoietic regeneration after myeloablative therapies.