Enhanced myelination potential of human mature oligodendrocytes by TNF and IFNG combination - PubMed
14 hours ago
- #myelination
- #oligodendrocytes
- #neuroinflammation
- TNF and IFNG combination enhances myelination potential of human mature oligodendrocytes (OLs).
- The cytokine combination reverses individual cytokine-mediated inhibition of ensheathment by A2B5+ progenitor cells.
- Increased expression of myelination-relevant genes, STAT and IRF transcription factors, and mature OL structural genes (MOBP and CNP) observed.
- TNF and IFNG combination reduces OPC signature genes in mature OLs compared to IFNG alone.
- JAK/STAT pathway inhibitor reverses the combination's effect on ensheathment.
- The combination induces a stronger immune signature in mature OLs than individual cytokines.
- Findings highlight the complex interplay of inflammatory responses in CNS repair and potential therapeutic modulation.