Association Between Saturated Fatty Acid Intake and MASLD: Mediating Roles of Insulin Resistance and Serum Albumin - PubMed
5 hours ago
- #Saturated Fatty Acids
- #MASLD
- #Insulin Resistance
- Higher intake of specific saturated fatty acids (SFAs) like C4:0, C6:0, C14:0, C16:0, and C18:0 is associated with increased odds of Metabolic dysfunction-associated steatotic liver disease (MASLD).
- Both weighted quantile sum (WQS) and quantile g-computation (QGC) models show a positive joint association of SFAs with MASLD, with C16:0 as a major contributor.
- Insulin resistance mediates 30.0%-47.4% of the association between SFAs and MASLD, while serum albumin accounts for 5.9%-8.0%.
- The study suggests that insulin resistance and serum albumin partially explain the link between SFA intake and MASLD, supporting precision dietary strategies for prevention.