Molecular regulation and physiological role of GOLPH3-mediated Golgi retention - PubMed
5 hours ago
- #Golgi trafficking
- #Glycosylation
- #Vertebrate development
- GOLPH3 is essential for retrograde trafficking of Golgi-resident glycosyltransferases by binding their cytosolic tails via a specific negatively charged surface.
- GOLPH3 function is regulated by antagonistic S-acylation events that control its membrane association topology, revealing a lipid-mediated mechanism for intra-Golgi trafficking.
- Depletion of GOLPH3 in mice leads to glycosylation defects, partial embryonic lethality, impaired growth, and reduced bone mineralization, highlighting its critical role in vertebrate development.