Activation of NF-κB signaling in tissue-resident memory T cells promotes recurrent psoriasis in mice - PubMed
5 hours ago
- #recurrent psoriasis
- #Trm cells
- #NF-κB signaling
- Recurrent psoriasis is driven by tissue-resident memory T (Trm) cells, particularly CD8+ Trm cells.
- NF-κB signaling activation in Trm cells promotes psoriasis recurrence by enhancing their differentiation and inhibiting cuproptosis.
- Imiquimod-induced recurrent psoriatic mice showed elevated CD8+ Trm cells and increased NF-κB pathway phosphorylation.
- NF-κB inhibitors reduced dermatitis severity and Trm cell levels, while agonists restored them.
- In vitro studies confirmed NF-κB inhibitors suppress Trm cell activation and inflammation.