Spatial and single-cell transcriptomic atlas of human suprachiasmatic nucleus - PubMed
2 days ago
- #human physiology
- #circadian clock
- #transcriptomics
- The study presents a molecular and cellular atlas of the adult human suprachiasmatic nucleus (SCN) using spatial transcriptomics and single-nucleus RNA sequencing.
- Seven distinct human SCN neuron subtypes were identified, each with unique transcriptomes and spatial distributions.
- Comparative analysis across humans, mice, and non-human primates revealed conserved functional segregation in the SCN regulated by LHX1 and RORB.
- The human SCN shows significant reorganization in its neuropeptide signaling network compared to other species.
- Integration of human SCN transcriptomes with GWAS data linked the AVP/NMS neuron subtype to the morningness chronotype.
- The findings provide foundational insights into the neural and molecular mechanisms of the human circadian clock.