Patient-specific alterations in blood plasma cfRNA profiles enable accurate classification of cancer patients and controls - PubMed
4 days ago
- #cancer detection
- #biomarkers
- #cell-free RNA
- Study examines blood plasma cfRNA profiles to distinguish cancer patients from controls.
- Analyzed 266 samples across 25 cancer types, with additional validation in independent cohorts.
- Found both cancer type-specific and general cfRNA alterations in patients.
- Identified 'biomarker tail genes' that strongly deviate from controls in individual patients.
- Number of altered genes per sample helps classify cancer vs. control samples.
- Approach validated in multiple cohorts, including prostate cancer and lymphoma.
- Highlights potential for personalized cancer detection using patient-specific RNA patterns.