Identification of Mitochondrial Dysfunction-Related Candidate Biomarkers and Analysis of the Immune Cell Infiltration in Epilepsy - PubMed
3 days ago
- #epilepsy biomarkers
- #mitochondrial dysfunction
- #immune cell infiltration
- The study identifies Nubpl and Tspo as candidate biomarkers for mitochondrial dysfunction in epilepsy.
- Using machine learning, these biomarkers were selected from MitD-related differentially expressed genes (MDR-DEGs).
- Immune infiltration analysis revealed increased levels of MDSCs and Tregs in epilepsy.
- Nubpl and Tspo expression correlated with immune cell subsets and were enriched in complement and coagulation cascades.
- Validation via RT-qPCR confirmed elevated Nubpl and Tspo in a rat model post-status epilepticus.