Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses - PubMed
3 hours ago
- #lifestyle
- #genetics
- #mental disorders
- Extensive genetic overlap exists between severe mental disorders (SMDs) and lifestyle factors, with differing effect patterns across diagnoses.
- Major depression (MD) is genetically correlated with less physical activity and more sedentary behavior.
- Schizophrenia (SCZ) and bipolar disorder (BIP) show opposite patterns: associations with less sedentary behavior, more physical activity, and healthier food intake.
- 551 shared genetic loci were identified, implicating neurodevelopment, synaptic, and neuronal properties.
- Lifestyle factors partially mediate the relationship between genetic risk for SMDs and body mass index (BMI) and lipids.