Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice - PubMed
2 hours ago
- #Cathelicidin
- #Immunothrombosis
- #Sepsis
- Sepsis involves an immunothrombosis cascade in lung microcirculation.
- Cathelicidin initiates immunothrombi via formyl-peptide receptors, aiding bacterial capture.
- Blocking cathelicidin reduces early death but leads to delayed uncontrolled infection.
- Leukotriene B4 amplifies immunothrombi; inhibiting it improves vascular compromise.
- Targeting the immunothrombosis cascade can reduce immunopathology while preserving defense.