K48 and K63 linkage-competed ubiquitination of BECN1 promotes circPDE4D-mediated autophagy in chronic obstructive pulmonary disease - PubMed
7 hours ago
- #COPD
- #circRNA
- #autophagy
- Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with limited treatment options.
- Circular RNA circPDE4D is downregulated in COPD and associated with reduced lung function.
- circPDE4D promotes autophagy, stress granule (SG) formation, and reduces inflammation in vitro and in vivo.
- circPDE4D binds with miR545-3p to regulate SMURF1, which influences apoptosis, autophagy, SG formation, and inflammation.
- SMURF1 interacts with BECN1, enhancing K63-linked ubiquitination while antagonizing K48-linked ubiquitination, affecting BECN1 stability.
- A regulatory feedback loop involving circPDE4D-miR545-3p-SMURF1-BECN1 underlies COPD pathology and offers potential therapeutic targets.