Atmospheric particulate matter impairs pulmonary barriers by triggering FTH1-mediated ferroptosis - PubMed
6 hours ago
- #PM2.5
- #Lung Injury
- #Ferroptosis
- PM2.5 exposure harms health by impairing lung function and disrupting lung tissue.
- Ferroptosis-mediated oxidative stress plays a critical role in PM2.5-induced lung injury.
- PM2.5 reduces junction proteins in airway epithelial cells, which can be reversed by ferroptosis inhibitor Fer-1.
- Alveolar macrophages exposed to PM2.5 show diminished phagocytic capacity, reversible with Fer-1.
- FTH1 is identified as a central regulator in PM2.5-induced lung injury.
- Increased pulmonary uptake and retention of PM2.5 correlate with more severe lung injuries.
- PM2.5 disrupts pulmonary barriers by promoting FTH1-mediated ferroptosis.