ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics - PubMed
3 hours ago
- #Mitochondria-associated membranes
- #ERO1α
- #Glioblastoma
- ERO1α expression is linked to poor survival in glioblastoma (GBM) patients.
- ERO1α regulates mitochondria-associated membrane (MAM) structure, dynamics, and calcium functions.
- ERO1α promotes GBM aggressiveness and enhances mitochondrial oxidative phosphorylation.
- Inhibition of ERO1α shows antitumour effects, highlighting a druggable vulnerability for GBM therapy.