Early risperidone exposure impairs cognitive function by perturbation of the gut microbiome and bile acids/tyrosine-PTP1B axis - PubMed
5 hours ago
- #Gut Microbiome
- #Risperidone
- #Cognitive Function
- Early risperidone exposure in mice leads to cognitive impairment and hippocampal dendritic architecture deficits.
- Risperidone causes gut microbiota dysbiosis and intestinal barrier damage, with specific bacterial species affected.
- Fecal microbiota transplantation (FMT) shows the gut microbiome's causal role in risperidone-induced cognitive deficits.
- Risperidone alters metabolites like tauroursodeoxycholic acid (TUDCA) and p-cresol in the brain, impacting cognitive function.
- TUDCA prevents cognitive impairment and ER stress, while p-cresol induces neuronal ER stress.
- Knockout of PTP1B ameliorates cognitive impairment and neurological damage caused by risperidone.
- The study highlights the risk of gut and neurological side effects of SGAs in children and adolescents.