Neuroimmune Dysregulation in Alzheimer's Disease: Mechanisms and Therapeutic Strategies - PubMed

3 months ago

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline.
Traditional research focused on β-amyloid (Aβ) deposition and tau protein hyperphosphorylation, but therapeutic failures have shifted focus to neuroimmune dysfunction.
Neuroimmune dysfunction is now recognized as a central driver in AD progression, contributing to neuroinflammation, synaptic damage, and cognitive decline.
The review highlights pathways of inflammation and neuroimmune dysregulation in AD, including gut microbiota dysbiosis and systemic immunity.
Emerging neuroimmune-targeted interventions include TREM2 activation, CD33 antagonists, and antisense oligonucleotides.
The study aims to provide a foundation for novel therapeutic approaches in AD.

Hasty Briefsbeta