Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction - PubMed
5 hours ago
- #mechanotransduction
- #TYK2
- #breast cancer
- TYK2 suppresses breast cancer metastasis under low ECM stiffness.
- High ECM stiffness causes TYK2 mislocalization and inactivation, promoting metastasis.
- TYK2 inhibition promotes invasion and metastasis independent of JAK/STAT signaling.
- TYK2 localization differs between normal breast epithelium (membrane) and invasive tumors (cytoplasmic).
- Findings suggest caution in using TYK2 inhibitors for breast cancer patients.