Liposomal hydrogel-based oral vaccine delivery for targeted induction of intestinal mucosal immunity - PubMed
14 hours ago
- #Liposomal Hydrogel
- #Mucosal Immunity
- #Oral Vaccine
- Development of a novel oral vaccine delivery platform (MLip@Gel) combining mannose-decorated liposomes with a thiolated alginate gel microsphere.
- The system targets intestinal macrophages, enhances antigen uptake, and protects the vaccine from stomach acid, releasing it in the intestines.
- Incorporation of retinoic acid (RA) promotes secretory IgA production, crucial for mucosal immunity.
- Demonstrated effectiveness in mice and piglets, showing high levels of immune cell activation and protection against PEDV infection.
- Induces both robust mucosal and systemic immune responses, offering a promising approach against intestinal infectious diseases.