Targeting Metabolic Reprogramming in Multiple myeloma: molecular mechanisms and potential therapeutic targets - PubMed
2 days ago
- #Therapeutic Targets
- #Metabolic Reprogramming
- #Multiple Myeloma
- Multiple myeloma (MM) is a hematologic malignancy with clonal proliferation of malignant plasma cells.
- Metabolic reprogramming is a critical factor in MM progression and drug resistance.
- The review covers molecular mechanisms of metabolic pathways in MM, including glucose, lipid, amino acid, nucleotide, and trace element metabolism.
- The gut microbiota's role as a distal regulator in disease progression is explored.
- Metabolic states provide functional insights beyond conventional staging systems, aiding in biomarker development and treatment selection.
- Metabolic vulnerabilities are positioned as conditional therapeutic targets in MM.