Stem Cell-Derived Exosomes Improve Neurological Dysfunction in a Rat Model of Moderate-to-Severe Cerebral Palsy - PubMed
6 hours ago
- #cerebral palsy
- #exosomes
- #stem cells
- Stem cell-derived exosomes (hUCMSC-Exos) show therapeutic effects in a rat model of moderate-to-severe cerebral palsy (CP).
- Treatment improved motor coordination and cognitive function, linked to enhanced remyelination and oligodendrocyte maturation.
- The therapy reduced neuroinflammatory responses (lowered TNF-α, IL-6) and increased brain-derived neurotrophic factor (BDNF).
- Study suggests hUCMSC-Exos as a dual-modality therapy targeting both motor and cognitive impairments in CP.
- Ethical approvals and informed consents were obtained for the use of human umbilical cord tissue.