BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance - PubMed
14 hours ago
- #BRCA1-A
- #cancer resistance
- #ecDNA
- BRCA1-A and LIG4 complexes are key drivers of extrachromosomal circular DNA (ecDNA) production.
- The BRCA1-A complex protects DNA ends from excessive resection, promoting end-joining for circularization.
- The MRN complex mediates end resection and suppresses ecDNA formation.
- LIG4 mediates ecDNA production by joining the free ends of DNA fragments.
- Disruption of LIG4 or BRCA1-A complex impairs ecDNA-mediated adaptation and resistance to cancer therapies.
- The study identifies therapeutic targets to block ecDNA-mediated adaptation in cancer treatment.