Neutrophil S100a9 Deficiency Protects against Periodontal Bone Loss - PubMed
5 hours ago
- #NETosis
- #S100A9
- #periodontitis
- Periodontitis is an inflammatory disease caused by microbial dysbiosis, leading to immune dysregulation and alveolar bone resorption.
- S100A8/A9 levels are upregulated in human periodontitis, but its role in osteoimmunological homeostasis was unclear.
- S100a9 knockout mice showed impaired neutrophil extracellular trap (NET) formation and reduced bone resorption.
- S100a9 deficiency inhibits neutrophil autophagy, leading to diminished NETosis, which suppresses osteoclast differentiation.
- Rapamycin-induced autophagy restoration reversed the effects in S100a9-deficient mice.
- The S100A9-specific inhibitor tasquinimod effectively inhibited osteoclast differentiation and mitigated bone loss.
- The study reveals S100A9 regulates osteoclast differentiation via NETosis, offering insights into periodontitis pathogenesis.