Conduction System Pacing Versus Biventricular Cardiac Resynchronization in HFmrEF: A Systematic Review and Meta-Analysis - PubMed
6 hours ago
- #cardiac resynchronization therapy
- #conduction system pacing
- #heart failure
- This systematic review and meta-analysis compares conduction system pacing (CSP) with biventricular pacing (BiVP) in patients with heart failure with mildly reduced ejection fraction (HFmrEF, LVEF 41%-49%).
- CSP, including His-bundle pacing and left bundle branch pacing, showed a reduction in heart failure hospitalization and improved composite outcomes of death or HFH compared to BiVP, while all-cause mortality was similar between groups.
- CSP resulted in greater QRS narrowing, trends toward functional improvement, and numerically lower device-related complications, suggesting its potential superiority in electrical resynchronization for HFmrEF.
- The findings are based on seven studies involving 1,867 patients, indicating a need for large randomized trials to confirm CSP as a standard resynchronization strategy.