Foxn3 is part of a transcriptional network that regulates primary cilia in the developing retina - PubMed
6 hours ago
- #Foxn3
- #Retina
- #Cilia
- Foxn3 is a transcriptional repressor involved in regulating primary cilia in the developing retina.
- Disruption of Foxn3 leads to additional displaced amacrine interneurons, retinal astrocytes, and ectopic primary cilia.
- Foxn3 and Rfx3 proteins bind to upregulated retinal genes linked to cilia structure or assembly.
- A shared hydrophobic motif (LXXLXWL) in Foxn3, Foxn4, and Foxj1 is essential for interaction with Rfx3 and transcriptional regulation.
- AlphaFold 3 predicts interaction between the hydrophobic motif and the Rfx3 dimerization domain.
- Mutations in Rfx3 disrupt its association with Foxn3, Foxn4, or Foxj1.
- Foxn3 limits primary cilia formation by repressing cilia genes in the developing retina.