Pathogenic GM-CSF drives functional diversification of inflammatory macrophages in autoimmune arthritis - PubMed
5 hours ago
- #Autoimmune Arthritis
- #Macrophage Diversification
- #GM-CSF
- GM-CSF drives the diversification of joint-infiltrating Ly6Chi monocytes into pathogenic macrophage subsets in autoimmune arthritis, rather than affecting their recruitment.
- Single-cell RNA sequencing identified two GM-CSF-dependent macrophage subpopulations: Arginase-1+ and EpCAM+ clusters, both producing proinflammatory cytokines and matrix metalloproteinases.
- EpCAM+ macrophages uniquely express Ccl17, a pronociceptive mediator linked to arthritic pain, highlighting GM-CSF's role in amplifying joint inflammation and pain.