Genetic and Molecular Interconnections Between Chronic Obstructive Pulmonary Disease and Osteoporosis: Insights from Single-Cell and Mendelian Randomization Analyses - PubMed
4 hours ago
- #Osteoporosis
- #COPD
- #Mendelian Randomization
- The study identifies shared upregulated (161) and downregulated (106) genes between COPD and osteoporosis using single-cell analysis.
- Mendelian randomization pinpoints PADI4 and TUBB2A as key causal genes linking the two conditions.
- The MAPK signaling pathway is highlighted as a critical shared pathway in both diseases.
- Molecular docking suggests strong binding of chemicals like BPA, TCDD, and estradiol to target proteins.
- NK cells are key in COPD while monocytes are central in osteoporosis, with distinct developmental trajectories.