c/EBPβ-driven Uchl3-mediated deubiquitination of TRPV1 promotes neuropathic pain by inducing mitochondrial fission in male rats - PubMed
6 hours ago
- #neuropathic pain
- #TRPV1
- #mitochondrial dynamics
- The study explores the c/EBPβ/Uchl3/TRPV1 axis in neuropathic pain (NP) via mitochondrial dynamics.
- TRPV1 activation promotes mitochondrial fission, dysfunction, and neuronal excitability, contributing to NP.
- Uchl3 stabilizes TRPV1 by deubiquitination, preventing its degradation and altering mitochondrial dynamics.
- c/EBPβ transcriptionally upregulates Uchl3, forming a regulatory cascade that influences NP.
- Intrathecal si-c/EBPβ in CCI rats downregulates c/EBPβ, Uchl3, and TRPV1, restoring mitochondrial homeostasis and alleviating pain.
- The findings suggest the c/EBPβ/Uchl3/TRPV1 pathway as a novel therapeutic target for NP treatment.