Development and validation of a 5mC-based prognostic model for lung adenocarcinoma survival - PubMed
6 hours ago
- #lung adenocarcinoma
- #prognostic model
- #DNA methylation
- Development of MethPro-LUAD, a prognostic model for lung adenocarcinoma based on eight 5-methylcytosine features.
- Model trained and tested using TCGA-LUAD data and validated across multiple independent cohorts and external datasets.
- Stratifies patients into high- and low-risk groups, with high-risk consistently showing shorter overall survival.
- Predictive performance remains robust across various subgroups and in disease-free survival analyses.
- Outperforms other reported prognostic models, offering potential for personalized treatment and clinical translation.