Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 - PubMed
5 hours ago
- #PCDH15
- #mechanotransduction
- #cryo-EM
- Cryo-EM shows PCDH15 forms a right-handed double helix dimer structure.
- Two PCDH15 molecules create a parallel cis dimer with multiple dimerization interfaces.
- Functional studies reveal mutations in dimerization domains impair mechanotransduction.
- The study provides structural evidence for tip link architecture in inner ear hair cells.