Predictors of mortality and therapeutic efficacy in carbapenem-resistant Acinetobacter baumannii bacteremia - PubMed
6 hours ago
- #mortality predictors
- #CRAB bacteremia
- #cefiderocol efficacy
- Study objective: Identify clinical and therapeutic factors influencing mortality in carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia.
- Study design: Prospective, observational, multicenter study in 52 Italian centers over 18 months with 398 adult patients.
- Key findings: 14-day mortality was 22%; 30-day mortality was 27%. Predictors of higher mortality included male sex, chronic kidney disease, septic shock, and previous Acinetobacter baumannii colonization.
- Treatment efficacy: Cefiderocol-containing regimens were linked to improved survival at both 14 and 30 days, and colistin-containing regimens to 14-day survival.
- Negative association: Tigecycline-containing regimen was associated with increased 30-day mortality.
- Combination therapy: Cefiderocol combined with fosfomycin was significantly associated with clinical success.
- Conclusion: The study provides insights into mortality predictors and effective treatments, guiding management of CRAB bacteremia.