Effects of PCSK9 inhibitors on vascular function, lipid profile, and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta-analysis - PubMed
10 hours ago
- #Cardiovascular outcomes
- #Peripheral artery disease
- #PCSK9 inhibitors
- PCSK9 inhibitors significantly reduced carotid IMT, LDL-C, total cholesterol, and triglycerides in PAD patients.
- No significant effects were observed on ABI, FMD, or HDL levels.
- PCSK9 inhibitors lowered the risk of MACE, major amputation, and myocardial infarction.
- Revascularization rates and all-cause mortality were not significantly affected.
- PCSK9 inhibitors may be effective adjunctive therapy for high-risk PAD populations.