Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice - PubMed
11 hours ago
- #neuroprotection
- #FGF21
- #lactate metabolism
- FGF21 plays a neuroprotective role in aging mice by enhancing lactate uptake and utilization.
- Aging mice show upregulated neuronal FGF21 expression and increased astrocyte-neuron lactate shuttle (ANLS) rate in hippocampal and cortical regions.
- Exogenous FGF21 administration improves learning, memory, and lactate metabolism in aging mice via MCT2 dependency.
- HCA1-KO mice show abolished CREB and MAPK signaling activation in lactate-infused mice, differing from aging mice.
- In vitro studies confirm p38-mediated FGF21 production and PI3K-mTOR-dependent MCT2 protein translation in aging.
- Increased FGF21 levels may help neurons combat age-related neuroinflammation and lactate accumulation.
- Lactate shuttle rate and microenvironment are linked to neuronal function, suggesting a therapeutic target for aging-related cognitive dysfunction.