Attributable Fraction of Epstein-Barr Virus in Subtypes of Lymphoma: A Systematic Review and Global Meta-Analysis - PubMed
6 hours ago
- #Epstein-Barr Virus
- #Meta-Analysis
- #Lymphoma
- The systematic review and meta-analysis evaluated the Epstein-Barr virus (EBV) attributable fraction across various lymphoma subtypes, covering studies from 1990 to 2024, and including over 21,140 lymphoma cases.
- In HIV-negative individuals, EBV prevalence ranged from 5.1% in follicular lymphoma to 92.4% in extranodal NK/T-cell lymphoma (ENKTL), with significant rates in Burkitt lymphoma (45.8%), Hodgkin lymphoma (53.0%), and plasmablastic lymphoma (52.5%).
- Persons living with HIV (PLHIV) exhibited higher EBV prevalence in Diffuse large B-cell lymphoma (43.6%), Burkitt lymphoma (43.3%), and plasmablastic lymphoma (79.4%) compared to HIV-negative cases.
- Regional heterogeneity in EBV positivity was only significant in Burkitt lymphoma, with near-universal EBV positivity observed in East African Burkitt lymphoma cases.
- The findings highlight EBV's substantial contribution to lymphoma burden, particularly in PLHIV, and inform public health strategies such as vaccine development, early diagnosis, and targeted therapies.